Cuba begins clinical trial of HIV vaccine

Create: 02/27/2017 - 05:42

HAVANA,Cuba (CMC) — A therapeutic vaccine aimed at reducing the viral load of patients with Human Immunodeficiency Virus (HIV), is currently in phase one of a clinical trial, in which its safety is studied.

According to Yayri Caridad Prieto Correa, a researcher from the Center for Genetic Engineering and Biotechnology (CIGB) here said that the nine patients involved in the trial did not show any adverse effects or toxicity, which is the main objective of the phase.

After preclinical studies in laboratory animals, and tests in the small group of humans, it was shown that the immune response of the organism is enhanced thanks to the use of the vaccine, although Prieto Correa insisted on not creating false expectations.

She told the Cuban News Agency that this is a multi-year project, and will take time which will include testing phases with a greater number of seropositives in which large-scale and comprehensive efficacy will be tested to determine whether or not to continue with its use.

Prieto Correa emphasised that the country’s scientific institutions, and in particular the CIGB should keep the search for vaccine candidates against HIV among its research priorities, although prevention is still the main method of avoiding contagion.

She added that the goal is to replace the current tripartite therapy, combining several methods that prevent the development of HIV, highly effective because the retroviral inhibitors block the spread of the virus, but can cause collateral damage and force in some cases the suspension of the treatment for a time.

The proposal presented by Prieto Correa and a team of researchers at the first Congress BioProcess 2017, which takes place in Camaguey, shows signs of efficacy, however she noted that it does not cure the disease.

Its administration is carried out simultaneously through the mucosal route, with the use of spray and intramuscular vaccination, and it has been preliminarily verified that it diminishes the viral load in the CD8 cells.

According to the Cuban Ministry of Public Health 31 years after the first case diagnosed in the country with HIV, transmission by blood and its derivatives and mother-to-child transmission were eliminated.

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